生命科学 / 医学

Tumor Evolutionary Tree (Subclonal Architecture)

Branched phylogeny showing parental clone diversifying into subclones under therapeutic pressure.

完整 Prompt

Create a tumor evolutionary tree diagram showing subclonal architecture under therapeutic pressure.

Layout:
- Left: founding clone at diagnosis, branching into subclones A, B, and C.
- Middle: treatment bottleneck with a highlighted therapeutic pressure band.
- Right: resistant relapse clone expanding after treatment.
- Add a small stacked bar chart under each time point showing clone fractions.
- Annotate driver mutations on selected branches, such as TP53, KRAS, EGFR, or MYC.
- Include sampling time points: diagnosis, treatment, minimal residual disease, relapse.

Style:
- Cancer genomics figure on white background.
- Use distinct clone colors, thin branch lines, and readable mutation callouts.
- Keep the tree visually clean and avoid excessive branch density.
- Suitable for oncology papers, clonal evolution reviews, and translational medicine slides.

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适用场景

For cancer evolution, drug-resistance and intratumor heterogeneity papers.

变体

Add cell-fraction stacked plot

Add a stacked area plot to the right of the tree showing each subclone's fraction of total cells over time, with the therapy line aligned to the same time axis.

使用建议

Place the therapy event line horizontally — it cleanly separates pre/post phases.
Color resistant subclones distinctly. Tree-only figures hide the therapeutic story.
Annotate trunk mutations only once. Repeating them on every branch clutters the figure.

常见问题

How do I show parallel evolution?

Annotate the same gene appearing on multiple independent branches with a small "*" symbol and a footnote: "convergent evolution at the marked branches".